Cantargia kommer starta klinisk fas I/IIa-studie i slutet - Finwire

Ett steg närmare ny behandling mot leukemi – Vetenskap och

CAN04 is a first-in-class fully humanized monoclonal antibody targeting IL1RAP, a co-receptor for the IL-1 receptor which is expressed on human cancer cells. CAN04 binds to IL1RAP with high affinity in a manner that blocks signal transduction from IL-1 and IL-33 into the cells. IL1RAP Peptide Modified Sequence N[+1.0]TTYC[+57.0]SK Modification Type Deamidated (N), Carbamidomethyl (C) Protein - Site of Modification 118, 122 Peptide - Site of Modification 1, 5 Peptide Start 118 Peptide End 124 Expression of IL1RAP in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. IL1RAP is overexpressed in various solid tumors, both on cancer cells and in the tumor microenvironment. CAN04 is a fully humanized antibody that binds IL1RAP with high affinity (Kd = 1.10 pM), disrupts IL1α and IL1β signaling (IC50 = 3.9 and 4.1 nM respectively) and is glycoengineered to mediate an enhanced antibody-dependent cellular cytotoxicity (ADCC, EC50 < 1 nM).

Il1rap cancer

20 Oct 2016 in non-small cell lung cancer, where the product candidate CAN04, a humanised antibody against the IL1RAP target molecule, has been av H Ågerstam · 2015 · Citerat av 67 — The interleukin 1 receptor accessory protein (IL1RAP), also called IL1R3, is a coreceptor of type 1 interleukin 1 receptor (IL1R1) and is The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education Target IL1RAP found on most solid tumor forms and leukemia. • IL1RAP signalling (IL-1, Source: WHO, The Global Cancer Observatory 2018. Targeted antibody therapy for cancer and inflammation Cantargia has shown that IL1RAP is present in non-small cell lung cancer, pancreatic cancer, breast Cantargia utvecklar antikroppar mot IL-1 receptor accessory protein (IL1RAP) för behandling av cancer. Sådana antikroppar, såsom Cantargias Postern “Antibody blockade of IL1RAP signaling reduces metastasis in a breast cancer model” av David Liberg, Per-Ola Önnervik, Matteo Riva, The antibody CAN04 binds IL1RAP with high affinity and functions as an anti-cancer agent through both ADCC and blockade of interleukin-1 Millares et al. Lung Cancer.

Secures all relevant IP on IL1RAP as a target for cancer therapy.

Cantargia presenterar nya positiva prekliniska data för

We have previously described IL1RAP as a target on solid tumors (e.g. pancreatic cancer, non-small cell lung cancer (NSCLC), triple-negative breast IL1RAP was found in the tumor microenvironment in all samples and approximately 80 % of the patients contained IL1RAP positive cancer cells. Single agent in vivo antitumor activity has previously been documented with CAN04 in e.g.

Cantargia kommer starta klinisk fas I/IIa-studie i slutet - Finwire

CAN04 is a humanized and antibody-dependent cellular cytotoxicity (ADCC)-enhanced IgG1 antibody targeting IL1RAP with two modes of action: blocking IL-1 alpha and beta signaling and triggering ADCC. IL1RAP as a target in cancer 15 The original finding: IL1RAP - a novel target on cancer cells Leukemic cells from patients Genomics & Bioinformatics IL1RAP identified as upregulated on CML leukemia stem cells Isolation of CML leukemia stem Cells based on IL1RAP expression Ewing Sarcoma (EWS) is an aggressive form of childhood cancer that occurs on bone and soft tissue. Although conventional cancer therapeutic strategies, such as chemotherapy, radiation and surgery, have improved survival in patients with localized EWS tumours, they are ineffective for patients with metastatic disease.

But within the large family of cancers (more than 200 different members), Myeloid Leukemia (AML & CML) diseases show specificity. A specificity that turns out to be an obstacle to therapeutic treatment. 2. IL1RAP is expressed in a number of tumor tissues, including lung and pancreatic cancer, both on tumor cells and on infiltrating immune cells. We have, using antibodies directed against IL1RAP, shown the ability to target and kill IL1RAP-expressing tumor cells by ADCC, to inhibit IL-1 signaling in those cells and to reduce growth of transplanted human tumors in vivo. Chronic tumor IL-1 signaling is involved in resistance to cancer therapies, immune evasion, and metastases.
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Although conventional cancer therapeutic strategies, such as chemotherapy, radiation and surgery, have improved survival in patients with localized EWS tumours, they are ineffective for patients with metastatic disease. In addition, conventional chemotherapy is often toxic and carcinogenic, which IL1RAP was found in the tumor microenvironment in all samples and approximately 80 % of the patients contained IL1RAP positive cancer cells.

Genetic variants in IL-1RAcP have been associated with prostate cancer, 16 Jun 2017 The program aims to develop an antibody that targets IL1RAP, against non- small-cell lung cancer (NSCLC) and pancreatic cancer, both as 10 Mar 2020 With IP purchase, Cantargia doubles down on IL1RAP target we have secured all relevant IP on IL1RAP as a target for cancer therapy.”.
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Cantargia acquires Cellerant IP on IL1RAP Placera - Avanza

cancer CAN04 bind tumor cells and microenvironment Several cells in the tumor overexpress IL1RAP and bind CAN04: • Cancer cells • Stroma cells • Myeloid cells IL1RAP found in several cancer forms • NSCLC • Pancreatic cancer • Colorectal cancer • Breast cancer • Liver Cancer • HNSCC • Esophagael cancer • Melanoma • Leukemia Chronic myeloid leukemia (CML) is a chronic disease resulting in myeloid cell expansion through expression of the BCR-ABL1 fusion transcript. Tyrosine kinase inhibitors (TKI) have significantly increased survival of patients with CML, and deep responders may consider stopping the treatment. However, more than 50% of patients relapse and restart TKI, subsequently suffering unknown toxicity 2018-02-12 · Thus, from the splicing regulation of SRSF10 on IL1RAP, our study revealed the function of mIL1RAP in CC and the interaction between AS and inflammatory pathways in cancer. SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis Oncogene . 2018 May;37(18):2394-2409. doi: 10.1038/s41388-017-0119-6. 2021-03-02 · The findings of this study support IL1RAP as a novel potential Alzheimer's disease target and highlight the use of amyloid PET as a valuable Alzheimer's disease endophenotype, particularly in a longitudinal framework.